产品货号：
Z29360
中文名称：
ULK3抗体
英文名称：
Anti-ULK3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ULK3 Antibody |
| 指标别名 | unc-51 like kinase 3;ULK3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC,FCM |
| 基因名称 | ULK3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at C-terminus of human ULK3 (427-454aa HTEVQNLMARAEYLKEQVKMRESRWEAD),different from the related mouse and rat sequences by four amino acids. |
| 实际分子量 | 53KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.In search of potential homologues to Drosophila and human Fu,people have cloned human serine/threonine kinase ULK3 and assessed its ability to regulate GLI transcription factors,mediators of SHH signaling.And ULK3 enhances endogenous and over-expressed GLI1 and GLI2 transcriptional activity in cultured cells,as assessed by GLI-luciferase reporter assay.Besides that,ULK3 alters subcellular localization of GLI1,as assessed by immunofluorescent staining and immunoblotting assays.It is showed that ULK3 is an autophosphorylated kinase and phosphorylates GLI proteins in vitro.Also,ULK3 catalytical activity is crucial for its function in SHH pathway.It is demonstrated that ULK3 is widely expressed and its expression is higher in a number of tissues where Shh signaling is known to be active.The data suggest that serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. |
| Uniprot ID | Q6PHR2 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | unc-51 like kinase 3 |
| 蛋白名全称 | Serine/threonine-protein kinase ULK3 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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